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Debio 1562-201:Lymphoma: Large B-Cell Lymphoma and Other Forms of NHL; Relapsed and/or Refractory

A Phase 2 Study to Evaluate the Efficacy and Tolerability of IMGN529 in Combination With Rituximab in Patients With Relapsed and/or Refractory Diffuse Large B-Cell Lymphoma and Other Forms of Non-Hodgkin's Lymphoma

Objective

Overview

A Multicenter Open-Label Phase 2 Study of IMGN529 in combination with rituximab in Patients with relapsed or refractory B-Cell lymphoma and Other Forms of Non-Hodgkin's Lymphoma. Study Arms: 1) Experimental: Phase 2 IMGN529 + Rituximab

Key Inclusion Criteria

For a patient to be eligible for participation in this study, all of the following criteria must apply.
  • For Part 1 of the study, participants must have histopathologically confirmed diagnosis of R/R, DLBCL, FL, MZL/MALT, MCL, or other Sponsor approved NHL subtypes according to the World Health Organization (WHO) classification 2008 for which standard measures do not exist or are no longer effective.
  • For Part 2 and Part 3 of the study, participants must have histopathologically and clinically confirmed diagnosis of relapsed DLBCL. Participants will be considered to have a relapsed disease if they showed a duration of response of at least 24 weeks after their first line of therapy. The following participants with relapsed DLBCL will be enrolled:

    1. Participants who received at least only one line of previous therapy and achieved either complete response (CR) or partial response (PR) for at least 24 weeks (from the last day of the last cycle) after their first line of therapy, but are not eligible for high dose chemotherapy with autologous stem cell transplantation (HD-ASCT)
    2. Participants who received more than one line of previous therapy (including HD-ASCT), and have achieved a duration of response (CR or PR) of at least 8 weeks (from the last day of the last cycle) after their last line of therapy
  • Participants must have evaluable or measurable disease in accordance with the International Working Group Guidelines for Lymphoma.
  • Participants must have received at least one but no more than six prior treatment regimens. Prior treatment with an anti-CD20 agent, either alone or in combination, is allowed.
  • Participants must have Eastern Cooperative Oncology Group (ECOG) Performance Status 0 - 2.
  • Participants who are Hepatitis B surface antigen positive (HBsAg+) (must be PCR negative) who are taking antivirals, are allowed to enroll.

Key Exclusion Criteria

A patient will not be eligible for participation in this study if any of the following criteria apply.
  • Participants with a diagnosis of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).
  • For Part 2 and Part 3 of the study, patients with primary refractory DLBCL (defined as progression of disease within 24 weeks after first line of treatment).
  • For Part 2 and Part 3 of the study, participants that are eligible to undergo first-time HD-ASCT.
  • For Part 2 and Part 3 of the study, participants with R/R FL, MZL/MALT, MCL, or any other NHL subtypes according to the WHO classification.
  • Participants with active hepatitis A, B or C infection.
  • Women who are pregnant or breastfeeding.
  • Participants who have received prior therapy with other anti-CD37-targeting therapy.
  • Participants who have known central nervous system, meningeal, or epidural disease including brain metastases.
  • Participants with impaired cardiac function or clinically significant cardiac disease.

Phase: II

Learn More

ClinicalTrials.Gov

                          IRB Protocol Number
                          Debio 1562-201
                          Principal Investigator(s)
                          Asim Pati, M.D

                          Clinical Trial Categories

                          • Hematologic Cancer
                          Sponsor(s)
                          Debiopharm International SA
                          How to Participate

                          Wanda Burdette, RN

                          864-560-6810

                          wburdette@gibbscc.org

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