This randomized phase II trial studies how well exercise and low-dose ibuprofen in improving cognitive impairment in patients with colorectal cancer that has not spread to other places in the body who are receiving chemotherapy. Anti-inflammatory agents, such as ibuprofen, may slow the decline of cognitive processes and diseases involving the brain. Exercise may also help alleviating cognitive difficulties during chemotherapy.
Key Inclusion Criteria
For a patient to be eligible for participation in this study, all of the following criteria must apply.
- Have a primary diagnosis of non-metastatic colorectal cancer and have had surgery and are now receiving adjuvant chemotherapy
- Report cognitive difficulties of 3 or higher (on a scale of 0 = ?Not Present? to 10 = ?As Bad As You Can Imagine?) to the REDCap Screening Form question, ?Are you currently experiencing any cognitive problems (such as in your memory, attention, concentration, multi-tasking) since your cancer diagnosis?? at chemotherapy cycle 2 or after
- Be scheduled to receive at least 6 weeks of oral or intravenous (IV) chemotherapy during the study intervention period; therapeutic clinical trial participants are allowed
- Agree not to take a daily dosage of an non-steroidal anti-inflammatory drug (NSAID) except 81 mg cardioprotective aspirin for the 6-week intervention period; (higher doses of an NSAID on an ?as needed? basis for acute pain management are permitted but should not exceed more than 1000 mg for one day per week)
- Have the approval of their treating physician to participate in exercise testing (i.e., 6-minute walk test) and a low to moderate intensity home-based walking and progressive resistance exercise program; (physician must sign eligibility checklist prior to registration)
- Have the approval of their treating physician to receive the 6 week ibuprofen/placebo regimen (200 mg twice a day and doses 8 hours apart); (physician must sign eligibility checklist prior to registration)
- Be able to swallow medication
- Be able to read English
- Not be pregnant or become pregnant during the study if the participant is a woman of child-bearing potential (i.e., women who are pre-menopausal or not surgically sterile); documentation of pregnancy can be taken from the medical record
- Have the ability to understand and to give written informed consent as assessed by the participant?s primary care physician or medical oncologist
Key Exclusion Criteria
A patient will not be eligible for participation in this study if any of the following criteria apply.