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P2Y12 (PRU - Platelet Reactivity Test)

SIM

20034 

CPT

85576 x2 

Synonyms

Plavix test; PRU test, Verify NOW P2Y12 

Specimen Type

Whole Blood 

Container

TWO Greiner 2.0 ml Blue Top tube 3.2% Sodium Citrate (Whole Blood) and one 3.0 ml EDTA lavender stopper tube (Whole Blood)

Collection Instructions

DO NOT SEND SPECIMENS THROUGH THE TUBE SYSTEM.

Volume

Greiner 2.0 ml Blue Top tube 3.2% Sodium Citrate drawn to the line on the tube.  EDTA lavender stopper tube: 2 ml whole blood Min: 1.0 ml 

Additional Information

Test Limitations - Patients with inherited platelet disorders such as von Willebrand Factor deficiency, Glanzmann Thrombasthenia have not been studied with the Verify Now PRU test.  Patients who have been treated with Glycoprotein llb/lla inhibitor drugs should not be tested until platelet function has recovered.

Patient Preparation

none

Specimen Processing Instructions

Room Temperature:  Whole Blood for both the Greiner Sodium Citrate tubes and the EDTA lavender tube.

Transport Requirements

Room Temperature

Specimen Stability

Room Temperature:  4 hours    

Rejection Criteria

•  Clotted Sample 
•  Insufficient volume 
•  Plasma has been removed. 
•  HCT AND PLATELET MUST BE WITHIN ACCEPTABLE TESTING RANGE.  ACCEPTABLE TESTING RANGE IS HCT = 33 – 52% AND PLATELETS = 119,000 – 502,000. 

Reference Range

Platelet Reaction Unit (PRU) test: 194 – 418

Patient results within this range represent individuals with no evidence of P2Y12 receptor blockade.  Patient results less than 194 indicate P2Y12 receptor blockade.

Critical Value

none 

Test Includes

P2Y12; HCT and Platelet for acceptable testing range for an accurate P2Y12 result. 

Methodology

Verify NOW instrument measures platelet P2Y12 receptor blockade. 

Testing Frequency

Daily, Monday - Sunday 

 

Reviewed By

Sandy Hammett 

Reviewed Date

2/2/2018

Supplemental

 

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