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Protein C *

SIM

15351 

CPT

85303 

Synonyms

Protein C Functional; Protein C Activity ;  

Specimen Type

Plasma 

Container

Blue-top (sodium citrate) tube

Collection Instructions

Blood should be collected in a blue-top tube containing 3.2 % buffered sodium citrate. Evacuated collection tubes must be filled to completion to ensure a proper blood to anticoagulant ratio. The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing. Do not draw from an arm with a heparin lock or heparinized catheter.

Volume

Volume: 2 ml. 
Minimum volume: 1 ml. 

Additional Information

Test is used for confirmation and characterization of protein C deficiency.

Patient Preparation

 Ideally the patient should not be on anticaogulant therapy.Avoid warfarin (Coumadin®) therapy for two weeks and heparin, direct Xa and thrombin therapies  for three days prior to the test.

Specimen Processing Instructions

 Once in the lab,separate plasma from cells as soon as possible.

Transport Requirements

Frozen

Specimen Stability

 Frozen :7 days 

Rejection Criteria

Gross hemolysis; clotted specimen; specimen not frozen; serum

Reference Range

Reference range accompanies report

Critical Value

 

Test Includes

Protein C  

Methodology

A specific enzyme extracted from the venom of Agkistrodon c. contortrix is used to activate PC in the patient sample. All other factors required for normal aPTT are supplied in the reagent. The activated protein C inhibits factors V and VIII in the reagent and the resultant prolongation of the a PTT-based clotting time is proportional to plasma PC activity

Testing Frequency

 

LCA

117705 

Reviewed By

Lisa McBride                 

Reviewed Date

2/20/2018

Supplemental

*  Denotes  Reference Lab Test

Reviewed by Lisa McBride on February 20, 2018

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